Keterkaitan antara Demokrasi Politik, Demokrasi Ekonomi dan Sistem Ekonomi Kerakyatan

Demokrasi politik merupakan syarat bagi berjalannya demokrasi ekonomi. Pelaksanaan demokrasi ekonomi akan terwujud bila terdapat kesejajaran antara sistem politik dan sistem ekonomi. Dalam sejarah perekonomian nasional, semangat demokrasi ekonomi sering dilanggar oleh menjurusnya sistem ekonomi nasional baik ke arah ekonomi kapitalistik atau ke sistem ekonomi terpusat. Sistem ekonomi kerakyatan yang bercirikan penegakan keadilan demokrasi ekonomi dan pemihakan terhadap yang lemah merupakan landasan dan sekaligus sebagai sarana bagi mewujudkan keadilan sosial bagi seluruh rakyat yang merupakan pilar utama demokrasi ekonomi

Keterkaitan antara Demokrasi Politik, Demokrasi Ekonomi dan Sistem Ekonomi Kerakyatan

Demokrasi politik merupakan syarat bagi berjalannya demokrasi ekonomi. Pelaksanaan demokrasi ekonomi akan terwujud bila terdapat kesejajaran antara sistem politik dan sistem ekonomi. Dalam sejarah perekonomian nasional, semangat demokrasi ekonomi sering dilanggar oleh menjurusnya sistem ekonomi nasional baik ke arah ekonomi kapitalistik atau ke sistem ekonomi terpusat. Sistem ekonomi kerakyatan yang bercirikan penegakan keadilan demokrasi ekonomi dan pemihakan terhadap yang lemah merupakan landasan dan sekaligus sebagai sarana bagi mewujudkan keadilan sosial bagi seluruh rakyat yang merupakan pilar utama demokrasi ekonomi

Agency in Transport Service: Implications of Traveller Mode Choice Objective and Latent Attributes Using Random Parameter Logit Model

Abstract: This paper explains how principal-agent theory (PAT) can be used as an analytical tool to understand the traveller-Transport for NSW (TfNSW) relationship and minimise the agency problem in the relationship by examining traveller preferences for mode choices. The paper emphasises latent variables (LVs) and traditional objective attributes (TOAs) together during the choice process within the agency relationship, as a method by which the utility of the principal (traveller) can be maximised and evaluated using a discrete choice experiment, i.e. random parameter logit (RPL) model. The probability of car use is significantly higher than public transport, which indicates that an agency problem exists in the relationship and incorporating traveller preferences in the transport projects may minimise this problem. Citation: Anwar, A.H.M., Tieu, K., Gibson, P., Win, K.T. & Berryman, M.J. (2014). Agency in Transport Service: Implications of Traveller Mode Choice Objective and Latent Attributes Using Ransom Parameter Logit Model. In: Campbell P. and Perez P. (Eds), Proceedings of the International Symposium of Next Generation Infrastructure, 1-4 October 2013, SMART Infrastructure Facility, University of Wollongong, Australia

Association between antimicrobial stewardship programs and antibiotic use globally: a systematic review and meta-analysis

IMPORTANCE: Antimicrobial resistance continues to spread rapidly at a global scale. Little evidence exists on the association of antimicrobial stewardship programs (ASPs) with the consumption of antibiotics across health care and income settings. OBJECTIVE: To synthesize current evidence regarding the association between antimicrobial stewardship programs and the consumption of antibiotics globally. DATA SOURCES: PubMed, Web of Science, and Scopus databases were searched from August 1, 2010, to Aug 1, 2020. Additional studies from the bibliography sections of previous systematic reviews were included. STUDY SELECTION: Original studies of the association of ASPs with antimicrobial consumption across health care and income settings. Animal and environmental studies were excluded. DATA EXTRACTION AND SYNTHESIS: Following the Preferred Reporting Items in Systematic Reviews and Meta-Analyses guideline, the pooled association of targeted ASPs with antimicrobial consumption was measured using multilevel random-effects models. The Effective Public Health Practice Project quality assessment tool was used to assess study quality. MAIN OUTCOMES AND MEASURES: The main outcome measures were proportion of patients receiving an antibiotic prescription and defined daily doses per 100 patient-days. RESULTS: Overall, 52 studies (with 1 794 889 participants) measured the association between ASPs and antimicrobial consumption and were included, with 40 studies conducted in high-income countries and 12 in low- and middle-income countries (LMICs). ASPs were associated with a 10% (95% CI, 4%-15%) reduction in antibiotic prescriptions and a 28% reduction in antibiotic consumption (rate ratio, 0.72; 95% CI, 0.56-0.92). ASPs were also associated with a 21% (95% CI, 5%-36%) reduction in antibiotic consumption in pediatric hospitals and a 28% reduction in World Health Organization watch groups antibiotics (rate ratio, 0.72; 95% CI, 0.56-0.92). CONCLUSIONS AND RELEVANCE: In this systematic review and meta-analysis, ASPs appeared to be effective in reducing antibiotic consumption in both hospital and nonhospital settings. Impact assessment of ASPs in resource-limited settings remains scarce; further research is needed on how to best achieve reductions in antibiotic use in LMICs

Characterizing and mapping cropping patterns in a complex agro-ecosystem: An iterative participatory mapping procedure using machine learning algorithms and MODIS vegetation indices

Accurate and up-to-date spatial agricultural information is essential for applications including agro-environmental assessment, crop management, and appropriate targeting of agricultural technologies. There is growing research interest in spatial analysis of agricultural ecosystems applying satellite remote sensing technologies. However, usability of information generated from many of remotely sensed data is often constrained by accuracy problems. This is of particular concern in mapping complex agro-ecosystems in countries where small farm holdings are dominated by diverse crop types. This study is a contribution to the ongoing efforts towards overcoming accuracy challenges faced in remote sensing of agricultural ecosystems. We applied time-series analysis of vegetation indices (Normalized Difference Vegetation Index (NDVI) and Enhanced Vegetation Index (EVI)) derived from the Moderate Resolution Imaging Spectrometer (MODIS) sensor to detect seasonal patterns of irrigated and rainfed cropping patterns in five townships in the Central Dry Zone of Myanmar, which is an important agricultural region of the country has been poorly mapped with respect to cropping practices. To improve mapping accuracy and map legend completeness, we implemented a combination of (i) an iterative participatory approach to field data collection and classification, (ii) the identification of appropriate size and types of predictor variables (VIs), and (iii) evaluation of the suitability of three Machine Learning algorithms: Support Vector Machine (SVM), Random Forest (RF), and C5.0 algorithms under varying training sample sizes. Through these procedures, we were able to progressively improve accuracy and achieve maximum overall accuracy of 95% When a small sized training dataset was used, accuracy achieved by RF was significantly higher compared to SVM and C5.0 (P < 0.01), but as sample size increased, accuracy differences among the three machine learning algorithms diminished. Accuracy achieved by use of NDVI was consistently better than that of EVI (P < 0.01). The maximum overall accuracy was achieved using RF and 8-days NDVI composites for three years of remote sensing data. In conclusion, our findings highlight the important role of participatory classification, especially in areas where cropping systems are highly diverse and differ over space and time. We also show that the choice of classifiers and size of predictor variables are essential and complementary to the participatory mapping approach in achieving desired accuracy of cropping pattern mapping in areas where other sources of spatial information are scarce

Direct Visualization of 3-Dimensional Force and Energy Map of a Single Molecular Switch

Mechanical properties of molecules adsorbed on materials surfaces are increasingly vital for the applications of molecular thin films. Here, we conduct a fundamental research to induce conformational change mechanically on a single molecule and quantify the driving force needed for such molecular shape switch via a low temperature (~ 5K) Scanning Tunneling Microscope (STM) and Qplus Atomic Force Microscope (Q+AFM). Our measurement maps a three-dimensional landscape for mechanical potential and force at single molecule level with high spatial resolution in all three dimensions of a few angstrom (10-10 m). Molecule TBrPP-Co (a cobalt porphyrin) deposited on an atomically clean gold substrate typically has two of its pentagon rings tilted upward and the other two downward. An atomically sharp tip of the STM/Q+AFM, which vibrates with a high frequency (~ 30kHz), is employed to scan the molecule at different heights with 0.1Å increment and meanwhile record tip-molecule interaction strength in the form of tip frequency change. When tip approaches to the threshold distance to the molecule, mechanical force become large enough and cause pentagon rings flip their direction. Due to the sensitive nature of tip-molecule interaction, the rings flipping can be directly visualized by STM, as rings tilting upward exhibit two bright protrusions in contrast to rings downward in image. By processing frequency change, we obtain a three-dimensional mechanical potential and force map for a single molecule with the resolution of angstrom level in all three dimensions. Our preliminary results indicate that an energy barrier of ~400meV needs to be overcome for rings flipping of TBrPP-Co.https://digitalcommons.odu.edu/gradposters2021_sciences/1015/thumbnail.jp

Experimental control of single-mode laser chaos by using continuous, time-delayed feedback

Control of chaos in the single-mode optically pumped far-infrared (NH3)-N-15 laser is experimentally demonstrated using continuous time-delay control. Both the Lorenz spiral chaos and the detuned period-doubling chaos exhibited by the laser have been controlled. While the laser is in the Lorenz spiral chaos regime the chaos has been controlled both such that the laser output is cw, with corrections of only a fraction of a percent necessary to keep it there, and to period one. The laser has also been controlled while in the period-doubling chaos regime, to both the period-one and -two states

Strangeness nuclear physics: a critical review on selected topics

Selected topics in strangeness nuclear physics are critically reviewed. This includes production, structure and weak decay of $\Lambda$--Hypernuclei, the $\bar K$ nuclear interaction and the possible existence of $\bar K$ bound states in nuclei. Perspectives for future studies on these issues are also outlined.Comment: 63 pages, 51 figures, accepted for publication on European Physical Journal

Design principles for riboswitch function

Scientific and technological advances that enable the tuning of integrated regulatory components to match network and system requirements are critical to reliably control the function of biological systems. RNA provides a promising building block for the construction of tunable regulatory components based on its rich regulatory capacity and our current understanding of the sequence–function relationship. One prominent example of RNA-based regulatory components is riboswitches, genetic elements that mediate ligand control of gene expression through diverse regulatory mechanisms. While characterization of natural and synthetic riboswitches has revealed that riboswitch function can be modulated through sequence alteration, no quantitative frameworks exist to investigate or guide riboswitch tuning. Here, we combined mathematical modeling and experimental approaches to investigate the relationship between riboswitch function and performance. Model results demonstrated that the competition between reversible and irreversible rate constants dictates performance for different regulatory mechanisms. We also found that practical system restrictions, such as an upper limit on ligand concentration, can significantly alter the requirements for riboswitch performance, necessitating alternative tuning strategies. Previous experimental data for natural and synthetic riboswitches as well as experiments conducted in this work support model predictions. From our results, we developed a set of general design principles for synthetic riboswitches. Our results also provide a foundation from which to investigate how natural riboswitches are tuned to meet systems-level regulatory demands

Understanding the treatment benefit of hyperimmune anti-influenza intravenous immunoglobulin (Flu-IVIG) for severe human influenza

Background: Antibody-based therapies for respiratory viruses are of increasing importance. The INSIGHT 006 trial administered anti-influenza hyperimmune intravenous immunoglobulin (Flu-IVIG) to patients hospitalized with influenza. Flu-IVIG treatment improved outcomes in patients with influenza B but showed no benefit for influenza A. Methods: To probe potential mechanisms of Flu-IVIG utility, sera collected from patients hospitalized with influenza A or B viruses (IAV or IBV) were analyzed for antibody isotype/subclass and Fcγ receptor (FcγR) binding by ELISA, bead-based multiplex, and NK cell activation assays. Results: Influenza-specific FcγR-binding antibodies were elevated in Flu-IVIG–infused IBV- and IAV-infected patients. In IBV-infected participants (n = 62), increased IgG3 and FcγR binding were associated with more favorable outcomes. Flu-IVIG therapy also improved the odds of a more favorable outcome in patients with low levels of anti-IBV Fc-functional antibody. Higher FcγR-binding antibody was associated with less favorable outcomes in IAV-infected patients (n = 50), and Flu-IVIG worsened the odds of a favorable outcome in participants with low levels of anti-IAV Fc-functional antibody. Conclusion: These detailed serological analyses provide insights into antibody features and mechanisms required for a successful humoral response against influenza, suggesting that IBV-specific, but not IAV-specific, antibodies with Fc-mediated functions may assist in improving influenza outcome. This work will inform development of improved influenza immunotherapies